| 2. Round | 16/01/2022 | Deportivo Saprissa | - | AD San Carlos | 1:2 | ||||
| 3. Round | 22/01/2022 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 |  |
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| 4. Round | 04/02/2022 | Guadalupe | - | AD San Carlos | 3:1 | ||||
| 5. Round | 11/02/2022 | AD San Carlos | - | CS Herediano | 1:1 |  |
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| 15. Round | 20/04/2022 | AD San Carlos | - | Guadalupe | 2:1 | ||||
| 16. Round | 24/04/2022 | CS Herediano | - | AD San Carlos | 1:1 |  |
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| 18. Round | 01/05/2022 | AD San Carlos | - | Municipal Grecia | 2:2 | ||||
| 19. Round | 04/05/2022 | Jicaral | - | AD San Carlos | 2:1 | ||||
| 20. Round | 09/05/2022 | AD San Carlos | - | CS Cartaginés | 3:2 | ||||
| 21. Round | 13/05/2022 | LD Alajuelense | - | AD San Carlos | 1:0 | ||||
| 22. Round | 15/05/2022 | AD San Carlos | - | Sporting FC | 2:1 |
Cuba