| 1. Round | 08/08/2021 | OGC Nice | - | Stade de Reims | 0:0 | ||||
| 2. Round | 14/08/2021 | Lille OSC | - | OGC Nice | 0:4 |  |
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| 6. Round | 19/09/2021 | OGC Nice | - | AS Monaco | 2:2 | |
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| 7. Round | 22/09/2021 | FC Lorient | - | OGC Nice | 1:0 | |
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| 8. Round | 25/09/2021 | AS Saint-Étienne | - | OGC Nice | 0:3 | ||||
| 10. Round | 17/10/2021 | ESTAC Troyes | - | OGC Nice | 1:0 | ||||
| 11. Round | 24/10/2021 | OGC Nice | - | Olympique Lyonnais | 3:2 |  |
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| 3. Round | 27/10/2021 | OGC Nice | - | Olympique Marseille | 1:1 | ||||
| 12. Round | 31/10/2021 | Angers SCO | - | OGC Nice | 1:2 | ||||
| 13. Round | 07/11/2021 | OGC Nice | - | Montpellier HSC | 0:1 | ||||
| 17. Round | 05/12/2021 | OGC Nice | - | RC Strasbourg | 0:3 | |
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| 18. Round | 12/12/2021 | Stade Rennais | - | OGC Nice | 1:2 | |
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| 19. Round | 22/12/2021 | OGC Nice | - | RC Lens | 2:1 | ||||
| 23. Round | 06/02/2022 | OGC Nice | - | Clermont Foot 63 | 0:1 | ||||
| 29. Round | 20/03/2022 | Olympique Marseille | - | OGC Nice | 2:1 | ||||
| 30. Round | 02/04/2022 | OGC Nice | - | Stade Rennais | 1:1 | ||||
| 31. Round | 10/04/2022 | RC Lens | - | OGC Nice | 3:0 |
Algeria