1. Round | 12/08/2021 | Balzan FC | - | Sliema Wanderers | 1:0 | ||||
2. Round | 20/08/2021 | Sliema Wanderers | - | Floriana FC | 0:0 | ||||
5. Round | 26/09/2021 | Sirens FC | - | Sliema Wanderers | 2:2 | ||||
7. Round | 24/10/2021 | St. Luċija FC | - | Sliema Wanderers | 0:0 | ||||
8. Round | 31/10/2021 | Sliema Wanderers | - | Mosta FC | 2:3 | ||||
9. Round | 20/11/2021 | Sliema Wanderers | - | Valletta FC | 0:3 dec. | ||||
10. Round | 27/11/2021 | Birkirkara FC | - | Sliema Wanderers | 2:0 | ||||
11. Round | 05/12/2021 | Sliema Wanderers | - | Hamrun Spartans | 0:2 | ||||
13. Round | 19/12/2021 | Floriana FC | - | Sliema Wanderers | 2:0 | ||||
14. Round | 18/01/2022 | Sliema Wanderers | - | Gżira United | 1:3 | ||||
15. Round | 22/01/2022 | Gudja United | - | Sliema Wanderers | 1:0 | ||||
16. Round | 29/01/2022 | Sliema Wanderers | - | Sirens FC | 1:0 | ||||
17. Round | 05/02/2022 | Hibernians FC | - | Sliema Wanderers | 1:0 | ||||
22. Round | 11/03/2022 | Hamrun Spartans | - | Sliema Wanderers | 3:1 |