| 1. Round | 09/07/2010 | Zorya Lugansk | - | PFK Sevastopol | 0:0 | ||||
| 2. Round | 17/07/2010 | PFK Sevastopol | - | Metalist Kharkiv | 0:0 | ||||
| 4. Round | 31/07/2010 | PFK Sevastopol | - | Dinamo Kiev | 0:3 | ||||
| 7. Round | 22/08/2010 | Karpaty Lviv | - | PFK Sevastopol | 2:1 | ||||
| 9. Round | 10/09/2010 | Volyn Lutsk | - | PFK Sevastopol | 1:0 | ||||
| 15. Round | 31/10/2010 | Tavriya Simferopol (1958-2014) | - | PFK Sevastopol | 2:1 | ||||
| 16. Round | 06/11/2010 | PFK Sevastopol | - | Zorya Lugansk | 0:1 | ||||
| 18. Round | 19/11/2010 | PFK Sevastopol | - | Arsenal Kiev | 0:2 | ||||
| 19. Round | 27/11/2010 | Dinamo Kiev | - | PFK Sevastopol | 2:0 |
Ukraine