| 1. Round | 22/07/2017 | FC Nitra | - | MŠK Žilina | 1:0 | ||||
| 2. Round | 29/07/2017 | MŠK Žilina | - | 1. FC Tatran Prešov | 2:3 | ||||
| 3. Round | 05/08/2017 | Zlaté Moravce | - | MŠK Žilina | 2:0 | ||||
| 5. Round | 20/08/2017 | FC DAC 1904 | - | MŠK Žilina | 4:2 |  |
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| 6. Round | 25/08/2017 | MŠK Žilina | - | Spartak Trnava | 3:1 | |
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| 8. Round | 16/09/2017 | MŠK Žilina | - | AS Trenčín | 5:1 | ||||
| 9. Round | 19/09/2017 | MFK Ružomberok | - | MŠK Žilina | 1:0 | ||||
| 10. Round | 24/09/2017 | MŠK Žilina | - | Slovan Bratislava | 3:2 | ||||
| 11. Round | 30/09/2017 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:1 | ||||
| 12. Round | 15/10/2017 | MŠK Žilina | - | FC Nitra | 2:0 | ||||
| 14. Round | 28/10/2017 | MŠK Žilina | - | Zlaté Moravce | 2:0 | ||||
| 15. Round | 05/11/2017 | FK Senica | - | MŠK Žilina | 4:1 | ||||
| 16. Round | 18/11/2017 | MŠK Žilina | - | FC DAC 1904 | 0:0 | ||||
| 18. Round | 02/12/2017 | MŠK Žilina | - | FK Železiarne Podbrezová | 1:0 | |
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| 19. Round | 09/12/2017 | AS Trenčín | - | MŠK Žilina | 5:2 |
Nigeria