| 4. Round | 24/09/2021 | Doxa Katokopias | - | Ethnikos Achna | 0:0 | ||||
| 5. Round | 02/10/2021 | Ethnikos Achna | - | Aris Limassol | 0:3 | ||||
| 6. Round | 18/10/2021 | APOEL Nikosia | - | Ethnikos Achna | 2:1 | ||||
| 7. Round | 23/10/2021 | Ethnikos Achna | - | AEL Limassol | 2:2 | ||||
| 8. Round | 31/10/2021 | AEK Larnaca | - | Ethnikos Achna | 1:0 | ||||
| 9. Round | 07/11/2021 | Ethnikos Achna | - | Omonia Nikosia | 0:2 |  |
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| 10. Round | 20/11/2021 | Paphos FC | - | Ethnikos Achna | 3:0 | ||||
| 17. Round | 15/01/2022 | Ethnikos Achna | - | APOEL Nikosia | 0:3 | ||||
| 18. Round | 22/01/2022 | AEL Limassol | - | Ethnikos Achna | 1:0 | ||||
| 19. Round | 29/01/2022 | Ethnikos Achna | - | AEK Larnaca | 0:0 | |
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| 20. Round | 07/02/2022 | Omonia Nikosia | - | Ethnikos Achna | 0:2 | ||||
| 21. Round | 13/02/2022 | Ethnikos Achna | - | Paphos FC | 0:1 | ||||
| 22. Round | 27/02/2022 | Olympiakos Nikosia | - | Ethnikos Achna | 0:0 | |
Cyprus