| 3. Round | 07/08/2021 | PFC Beroe | - | Cherno More Varna | 0:2 | ||||
| 4. Round | 16/08/2021 | Cherno More Varna | - | Lokomotiv Plovdiv | 0:0 |  |
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| 5. Round | 21/08/2021 | CSKA 1948 Sofia | - | Cherno More Varna | 2:3 |  |
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| 6. Round | 29/08/2021 | Cherno More Varna | - | CSKA Sofia | 0:1 |  |
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| 8. Round | 18/09/2021 | Cherno More Varna | - | Lokomotiv Sofia | 1:1 | ||||
| 9. Round | 27/09/2021 | Pirin Blagoevgrad | - | Cherno More Varna | 2:2 | ||||
| 10. Round | 02/10/2021 | Arda Kardzhali | - | Cherno More Varna | 0:3 | ||||
| 11. Round | 17/10/2021 | Cherno More Varna | - | Slavia Sofia | 1:1 | |
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| 12. Round | 23/10/2021 | Botev Vratsa | - | Cherno More Varna | 0:0 | ||||
| 13. Round | 30/10/2021 | Cherno More Varna | - | Levski Sofia | 1:0 | ||||
| 14. Round | 06/11/2021 | Cherno More Varna | - | Tsarsko Selo Sofia | 1:1 | ||||
| 15. Round | 20/11/2021 | Botev Plovdiv | - | Cherno More Varna | 0:2 | ||||
| 16. Round | 26/11/2021 | Cherno More Varna | - | PFC Beroe | 1:0 | ||||
| 17. Round | 01/12/2021 | Lokomotiv Plovdiv | - | Cherno More Varna | 1:1 | ||||
| 18. Round | 06/12/2021 | Cherno More Varna | - | CSKA 1948 Sofia | 2:0 | ||||
| 19. Round | 12/12/2021 | CSKA Sofia | - | Cherno More Varna | 2:0 |
Guinea-Bissau