| 5. Round | 02/01/2021 | ENPPI | - | Zamalek | 1:2 | ||||
| 6. Round | 08/01/2021 | Wadi Degla SC | - | ENPPI | 1:2 | ||||
| 7. Round | 15/01/2021 | ENPPI | - | Ceramica Cleopatra | 2:1 | ||||
| 11. Round | 03/02/2021 | ENPPI | - | Pyramids FC | 3:2 | ||||
| 12. Round | 08/02/2021 | Smouha Sporting Club | - | ENPPI | 1:1 | ||||
| 14. Round | 21/02/2021 | Ismaily | - | ENPPI | 1:1 | ||||
| 8. Round | 25/02/2021 | El Entag El Harby | - | ENPPI | 0:0 | ||||
| 22. Round | 14/05/2021 | Zamalek | - | ENPPI | 3:1 | ||||
| 23. Round | 21/05/2021 | ENPPI | - | Wadi Degla SC | 0:0 | ||||
| 24. Round | 26/05/2021 | Ceramica Cleopatra | - | ENPPI | 0:2 | ||||
| 25. Round | 30/05/2021 | ENPPI | - | El Entag El Harby | 1:1 | ||||
| 30. Round | 14/08/2021 | Al Ahly SC | - | ENPPI | 2:0 | ||||
| 31. Round | 17/08/2021 | ENPPI | - | Ismaily | 2:1 | ||||
| 32. Round | 20/08/2021 | ENPPI | - | Tala'ea El Gaish SC | 1:1 |
Tunisia