| 4. Round | 21/08/2010 | Sporting Lokeren | - | RSC Anderlecht | 0:3 | ||||
| 5. Round | 28/08/2010 | RSC Anderlecht | - | SV Zulte Waregem | 0:0 | ||||
| 6. Round | 10/09/2010 | Sint-Truidense VV | - | RSC Anderlecht | 0:2 | ||||
| 7. Round | 19/09/2010 | RSC Anderlecht | - | KV Kortrijk | 3:0 | ||||
| 8. Round | 22/09/2010 | Lierse SK (old) | - | RSC Anderlecht | 1:1 | ||||
| 11. Round | 17/10/2010 | Cercle Brugge | - | RSC Anderlecht | 1:0 | ||||
| 16. Round | 20/11/2010 | Germinal Beerschot | - | RSC Anderlecht | 0:1 | ||||
| 17. Round | 27/11/2010 | RSC Anderlecht | - | Sporting Charleroi | 4:1 | ||||
| 29. Round | 12/03/2011 | KAS Eupen | - | RSC Anderlecht | 1:1 | ||||
| 30. Round | 20/03/2011 | RSC Anderlecht | - | KAA Gent | 3:2 |
Belgium
Congo DR