| 1. Round | 11/09/2021 | Panathinaikos | - | Apollon Smyrnis | 4:0 | ||||
| 2. Round | 18/09/2021 | PAS Giannina | - | Panathinaikos | 1:0 |  |
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| 4. Round | 26/09/2021 | Panathinaikos | - | Volos NFC | 5:1 | ||||
| 5. Round | 03/10/2021 | Olympiakos Piraeus | - | Panathinaikos | 0:0 | ||||
| 6. Round | 16/10/2021 | Panathinaikos | - | Ionikos Nikea | 4:1 | |
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| 7. Round | 23/10/2021 | Asteras Tripolis | - | Panathinaikos | 2:1 | ||||
| 8. Round | 31/10/2021 | Panathinaikos | - | OFI Heraklion | 0:0 | |
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| 9. Round | 07/11/2021 | Panathinaikos | - | PAOK Saloniki | 1:3 | ||||
| 10. Round | 22/11/2021 | Lamia | - | Panathinaikos | 1:3 | |
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| 11. Round | 28/11/2021 | Panathinaikos | - | Panetolikos | 2:0 | ||||
| 12. Round | 05/12/2021 | AEK Athen | - | Panathinaikos | 1:0 | ||||
| 13. Round | 11/12/2021 | Panathinaikos | - | Atromitos | 2:0 | ||||
| 24. Round | 19/02/2022 | Panetolikos | - | Panathinaikos | 1:0 | ||||
| 26. Round | 06/03/2022 | Atromitos | - | Panathinaikos | 0:2 |
Croatia