1st(1st leg) KS Besëlidhja Lezhë - KF Apolonia Fier 0:1
2nd (2nd leg) KF Apolonia Fier - KS Besëlidhja Lezhë -:-
1st(1st leg): 25/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) Flamurtari Vlorë - FK Vllaznia 2:1
2nd (2nd leg) FK Vllaznia - Flamurtari Vlorë -:-
1st(1st leg): 26/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) KS Pogradeci - KF Bylis Ballsh 0:3
2nd (2nd leg) KF Bylis Ballsh - KS Pogradeci -:-
1st(1st leg): 26/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) KS Besa - KS Korabi Peshkopi 1:1
2nd (2nd leg) KS Korabi Peshkopi - KS Besa -:-
1st(1st leg): 26/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) Labëria FC - FK Kukësi 0:3
2nd (2nd leg) FK Kukësi - Labëria FC -:-
1st(1st leg): 26/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) Luzi United - KF Teuta Durrës 0:0
2nd (2nd leg) KF Teuta Durrës - Luzi United -:-
1st(1st leg): 26/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) KF Maliqi - KF Skënderbeu 1:5
2nd (2nd leg) KF Skënderbeu - KF Maliqi -:-
1st(1st leg): 26/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) Turbina Cërrik - Erzeni Shijak 1:2
2nd (2nd leg) Erzeni Shijak - Turbina Cërrik -:-
1st(1st leg): 26/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) KF Devolli - KF Laçi 0:2
2nd (2nd leg) KF Laçi - KF Devolli -:-
1st(1st leg): 26/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) KS Kastrioti - FK Vora 1:0
2nd (2nd leg) FK Vora - KS Kastrioti -:-
1st(1st leg): 26/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) KF Oriku - FK Partizani 0:0
2nd (2nd leg) FK Partizani - KF Oriku -:-
1st(1st leg): 28/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) Butrinti Sarandë - Dinamo Tiranë 0:1
2nd (2nd leg) Dinamo Tiranë - Butrinti Sarandë -:-
1st(1st leg): 28/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) KF Lushnja - KF Tërbuni Pukë 2:0
2nd (2nd leg) KF Tërbuni Pukë - KF Lushnja -:-
1st(1st leg): 28/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) KS Shkumbini - Egnatia Rrogozhine 0:3
2nd (2nd leg) Egnatia Rrogozhine - KS Shkumbini -:-
1st(1st leg): 28/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) KS Burreli - FK Tomori Berat 2:1
2nd (2nd leg) FK Tomori Berat - KS Burreli -:-
1st(1st leg): 28/09/2022 14:00 2nd (2nd leg): 12/10/2022
1st(1st leg) KF Veleçiku Koplik - KF Tiranë 0:3
2nd (2nd leg) KF Tiranë - KF Veleçiku Koplik -:-
1st(1st leg): 28/09/2022 14:00 2nd (2nd leg): 12/10/2022