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| 1st(1st leg) | Standard Liège | - | KV Mechelen | 2:0 (1:0) | ||
| 2nd (2nd leg) | KV Mechelen | - | Standard Liège | 1:4 (0:0) | ||
| 1st(1st leg): 26/01/2011 19:30 | 2nd (2nd leg): 02/03/2011 19:30 | Winner: Standard Liège | ||||
| 1st(1st leg) | KVC Westerlo | - | Lierse SK | 1:2 (1:1) | ||
| 2nd (2nd leg) | Lierse SK | - | KVC Westerlo | 2:3 (1:1) | ||
| 1st(1st leg): 26/01/2011 19:30 | 2nd (2nd leg): 02/03/2011 19:45 | Winner: KVC Westerlo | ||||
| 1st(1st leg) | Cercle Brugge | - | Germinal Beerschot | 2:0 (2:0) | ||
| 2nd (2nd leg) | Germinal Beerschot | - | Cercle Brugge | 1:1 (0:0) | ||
| 1st(1st leg): 26/01/2011 19:30 | 2nd (2nd leg): 02/03/2011 19:30 | Winner: Cercle Brugge | ||||
| 1st(1st leg) | R. White Star Woluwe FC | - | KAA Gent | 0:2 (0:0) | ||
| 2nd (2nd leg) | KAA Gent | - | R. White Star Woluwe FC | 1:0 (1:0) | ||
| 1st(1st leg): 26/01/2011 19:30 | 2nd (2nd leg): 02/03/2011 19:30 | Winner: KAA Gent | ||||
