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| 1st(1st leg) | KAA Gent | - | RSC Anderlecht | 1:1 (1:1) | ||
| 2nd (2nd leg) | RSC Anderlecht | - | KAA Gent | 1:0 (1:0) | ||
| 1st(1st leg): 11/12/2012 19:00 | 2nd (2nd leg): 16/01/2013 19:00 | Winner: RSC Anderlecht | ||||
| 1st(1st leg) | Cercle Brugge | - | KV Oostende | 2:1 (1:0) | ||
| 2nd (2nd leg) | KV Oostende | - | Cercle Brugge | 1:2 (0:0) | ||
| 1st(1st leg): 12/12/2012 19:00 | 2nd (2nd leg): 16/01/2013 19:00 | Winner: Cercle Brugge | ||||
| 1st(1st leg) | Sint-Truidense VV | - | KV Kortrijk | 0:0 (0:0) | ||
| 2nd (2nd leg) | KV Kortrijk | - | Sint-Truidense VV | 1:0 (0:0) | ||
| 1st(1st leg): 12/12/2012 19:30 | 2nd (2nd leg): 16/01/2013 19:00 | Winner: KV Kortrijk | ||||
| 1st(1st leg) | SV Zulte Waregem | - | KRC Genk | 0:5 (0:3) | ||
| 2nd (2nd leg) | KRC Genk | - | SV Zulte Waregem | 0:1 (0:0) | ||
| 1st(1st leg): 13/12/2012 19:45 | 2nd (2nd leg): 16/01/2013 19:00 | Winner: KRC Genk | ||||
