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| 14/09/2010 | 15:00 | Zrinjski Mostar | - | Budućnost Banovici | 3:1 | |
| 18:00 | Željezničar Sarajevo | - | FK Rudar | 2:0 | ||
| 15/09/2010 | 15:00 | Borac Banja Luka | - | NK TOSK Tesanj | 2:0 | |
| 15:00 | FK Bosna | - | Sloboda Tuzla | 0:1 | ||
| 15:00 | HNK Branitelj | - | Doboj Istok | 7:0 | ||
| 15:00 | BSK Banja Luka | - | Omladinac Mionica | 0:2 | ||
| 15:00 | Čelik Zenica | - | Velež Mostar | 2:0 | ||
| 15:00 | FK Sarajevo | - | HNK Sloga | 2:1 | ||
| 15:00 | Slavija Sarajevo | - | NK Jedinstvo | 3:1 | ||
| 15:00 | Leotar Trebinje | - | Zvijezda Gradačac | 1:0 | ||
| 15:00 | NK Travnik | - | FK Kozara | 0:1 | ||
| 15:00 | Proleter Teslić | - | FK Drina | 4:3 pso | ||
| 15:00 | UNIS Vogošća | - | FK Modriča | 2:1 | ||
| 15:00 | NK Vitez | - | Olimpic Sarajevo | 0:1 | ||
| 15:00 | Široki Brijeg | - | FK Sutjeska Foča | 6:0 | ||
| 15:00 | Sloboda Novi Grad | - | HNK Orašje | 1:0 |
