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| 1st(1st leg) | Neman Grodno | - | BATE Borisov | 2:1 (0:1) | ||
| 2nd (2nd leg) | BATE Borisov | - | Neman Grodno | 2:0 (1:0) | ||
| 1st(1st leg): 06/04/2022 15:00 | 2nd (2nd leg): 27/04/2022 17:30 | Winner: BATE Borisov | ||||
| 1st(1st leg) | FK Gomel | - | FK Vitebsk | 2:0 (1:0) | ||
| 2nd (2nd leg) | FK Vitebsk | - | FK Gomel | 1:0 (0:0) | ||
| 1st(1st leg): 07/04/2022 15:00 | 2nd (2nd leg): 27/04/2022 15:00 | Winner: FK Gomel | ||||
