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| 1st(1st leg) | Valledupar FC | - | Fortaleza FC | 0:2 (0:1) | ||
| 2nd (2nd leg) | Fortaleza FC | - | Valledupar FC | 1:1 (1:1) | ||
| 1st(1st leg): 02/03/2022 21:00 | 2nd (2nd leg): 17/03/2022 22:30 | Winner: Fortaleza FC | ||||
| 1st(1st leg) | Boyacá Chicó | - | Real Santander | 0:1 (0:0) | ||
| 2nd (2nd leg) | Real Santander | - | Boyacá Chicó | 2:1 (1:0) | ||
| 1st(1st leg): 02/03/2022 23:00 | 2nd (2nd leg): 15/03/2022 19:00 | Winner: Real Santander | ||||
| 1st(1st leg) | Atlético Huila | - | Tigres FC | 0:2 (0:1) | ||
| 2nd (2nd leg) | Tigres FC | - | Atlético Huila | 2:0 (0:0) | ||
| 1st(1st leg): 03/03/2022 22:30 | 2nd (2nd leg): 16/03/2022 00:40 | Winner: Tigres FC | ||||
| 1st(1st leg) | Deportes Quindío | - | Llaneros FC | 3:0 (2:0) | ||
| 2nd (2nd leg) | Llaneros FC | - | Deportes Quindío | 2:0 (2:0) | ||
| 1st(1st leg): 04/03/2022 00:40 | 2nd (2nd leg): 17/03/2022 20:00 | Winner: Deportes Quindío | ||||
