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| 1st(1st leg) | Independiente Medellín | - | Jaguares de Córdoba | -:- | ||
| 2nd (2nd leg) | Jaguares de Córdoba | - | Independiente Medellín | -:- | ||
| 1st(1st leg): 30/07/2025 | 2nd (2nd leg): 06/08/2025 | |||||
| 1st(1st leg) | Santa Fe | - | Internacional de Palmira | -:- | ||
| 2nd (2nd leg) | Internacional de Palmira | - | Santa Fe | -:- | ||
| 1st(1st leg): 30/07/2025 | 2nd (2nd leg): 06/08/2025 | |||||
| 1st(1st leg) | Deportes Tolima | - | Real Soacha Cundinamarca | -:- | ||
| 2nd (2nd leg) | Real Soacha Cundinamarca | - | Deportes Tolima | -:- | ||
| 1st(1st leg): 30/07/2025 | 2nd (2nd leg): 06/08/2025 | |||||
| 1st(1st leg) | Millonarios | - | Real Cartagena | -:- | ||
| 2nd (2nd leg) | Real Cartagena | - | Millonarios | -:- | ||
| 1st(1st leg): 30/07/2025 | 2nd (2nd leg): 06/08/2025 | |||||
| 1st(1st leg) | América de Cali | - | Tigres FC | -:- | ||
| 2nd (2nd leg) | Tigres FC | - | América de Cali | -:- | ||
| 1st(1st leg): 30/07/2025 | 2nd (2nd leg): 06/08/2025 | |||||
| 1st(1st leg) | Atlético Junior | - | Atlético Huila | -:- | ||
| 2nd (2nd leg) | Atlético Huila | - | Atlético Junior | -:- | ||
| 1st(1st leg): 30/07/2025 | 2nd (2nd leg): 06/08/2025 | |||||
| 1st(1st leg) | Atlético Nacional | - | Cúcuta Deportivo | -:- | ||
| 2nd (2nd leg) | Cúcuta Deportivo | - | Atlético Nacional | -:- | ||
| 1st(1st leg): 30/07/2025 | 2nd (2nd leg): 05/08/2025 | |||||
| 1st(1st leg) | Once Caldas | - | Patriotas FC | -:- | ||
| 2nd (2nd leg) | Patriotas FC | - | Once Caldas | -:- | ||
| 1st(1st leg): 30/07/2025 | 2nd (2nd leg): 06/08/2025 | |||||
