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| 1st(1st leg) | NK Varaždin | - | HNK Rijeka | 2:1 (2:1) | ||
| 2nd (2nd leg) | HNK Rijeka | - | NK Varaždin | 2:4 (1:1) | ||
| 1st(1st leg): 09/11/2010 16:00 | 2nd (2nd leg): 24/11/2010 15:00 | Winner: NK Varaždin | ||||
| 1st(1st leg) | NK Istra 1961 | - | HNK Cibalia | 2:3 (0:2) | ||
| 2nd (2nd leg) | HNK Cibalia | - | NK Istra 1961 | 2:0 (2:0) | ||
| 1st(1st leg): 10/11/2010 13:00 | 2nd (2nd leg): 24/11/2010 15:00 | Winner: HNK Cibalia | ||||
| 1st(1st leg) | NK Zagreb | - | Slaven Belupo | 1:1 (0:1) | ||
| 2nd (2nd leg) | Slaven Belupo | - | NK Zagreb | 5:1 (1:1) | ||
| 1st(1st leg): 10/11/2010 16:00 | 2nd (2nd leg): 23/11/2010 15:00 | Winner: Slaven Belupo | ||||
| 1st(1st leg) | Dinamo Zagreb | - | NK Osijek | 2:0 (1:0) | ||
| 2nd (2nd leg) | NK Osijek | - | Dinamo Zagreb | 1:3 (1:1) | ||
| 1st(1st leg): 23/11/2010 16:00 | 2nd (2nd leg): 09/12/2010 13:30 | Winner: Dinamo Zagreb | ||||
