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| 14/09/2021 | 15:00 | Nehaj Senj | - | HNK Gorica | 3:7 (3:2) | |
| 15/09/2021 | 15:00 | NK Bednja Beletinec | - | NK Osijek | 0:3 (0:2) | |
| 21/09/2021 | 14:00 | NK Pitomača | - | HNK Rijeka | 0:7 (0:2) | |
| 14:30 | NK Dugopolje | - | Lokomotiva Zagreb | 7:8 (0:1, 1:1, 1:1) pso | ||
| 14:30 | NK Vuteks Sloga | - | NK Istra 1961 | 0:3 (0:0) | ||
| 14:30 | Mladost Ždralovi | - | NK Inter Zaprešić | 3:1 (3:0) | ||
| 16:00 | Primorac Biograd | - | Hajduk Split | 1:2 (1:1) | ||
| 22/09/2021 | 14:30 | NK Sesvete | - | NK Varaždin | 2:3 (0:1, 2:2) aet | |
| 14:30 | NK Belišce | - | NK Vinogradar | 4:0 (3:0) | ||
| 14:30 | NK Bjelovar | - | NK Rudeš | 1:5 (0:3) | ||
| 14:30 | NK BSK Bijelo Brdo | - | HNK Cibalia | 1:0 (1:0) | ||
| 14:30 | NK Zagreb | - | NK Oriolik | 0:1 (0:1) | ||
| 15:00 | HNK Orijent Rijeka | - | Dinamo Zagreb | 1:4 (0:1) | ||
| 15:30 | NK Rudar Labin | - | RNK Split | 2:0 (2:0) | ||
| 17:00 | NK Međimurje | - | HNK Šibenik | 0:1 (0:1) | ||
| 17:30 | NK Karlovac | - | Slaven Belupo | 0:2 (0:1) |
