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| 31/08/2022 | 15:30 | NK Sava Strmec | - | NK Bednja Beletinec | 4:6 (2:0) | |
| 15:30 | NK Moslavina Kutina | - | NK Međimurje | 3:2 (1:1) | ||
| 15:30 | NK Solin | - | NK Funtana | 6:1 (3:0) | ||
| 15:30 | Nehaj Senj | - | Primorac Biograd | 0:4 (0:1) | ||
| 15:30 | NK Neretva | - | NK Grobničan | 0:2 (0:0) | ||
| 15:30 | NK BSK Bijelo Brdo | - | NK Marsonia | 5:1 (2:0) | ||
| 15:30 | NK Križevci | - | NK Dubrava | 1:3 (1:1) | ||
| 15:30 | NK Nedelišće | - | NK Varteks | 5:4 (1:2, 2:2, 3:3) pso | ||
| 15:30 | NK Virovitica | - | Mladost Ždralovi | 0:6 (0:3) | ||
| 15:30 | NK Tehničar 1974 | - | NK Mladost Petrinja | 4:0 (3:0) | ||
| 15:30 | NK Belišce | - | BSK Buk | 3:0 (3:0) | ||
| 15:30 | NK Bjelovar | - | NK Gaj Mace | 1:0 (0:0, 0:0) aet | ||
| 15:30 | Slavonac Bukovlje | - | NK Borinci Jarmina | 0:2 (0:2) | ||
| 15:30 | NK Papuk Orahovica | - | NK Karlovac | 4:2 (0:0, 0:0, 0:0) pso | ||
| 15:30 | NK Vuteks Sloga | - | Jadran Poreč | 1:2 (1:1) | ||
| 15:30 | NK Bistra | - | NK Vodice | 2:1 (1:1) |
