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| 05/10/2022 | 16:00 | Othellos Athienou | - | Doxa Katokopias | 1:3 (0:0, 1:1) aet | |
| 16:00 | AE Zakakiou | - | Paphos FC | 0:3 (0:2) | ||
| 06/10/2022 | 15:00 | AEL Limassol | - | Ermis Aradippou | 1:0 (1:0) | |
| 11/10/2022 | 15:00 | PO Achyronas-Onisilos | - | APOEL Nikosia | 0:3 (0:1) | |
| 12/10/2022 | 15:00 | Nea Salamina | - | Peyia 2014 | 3:1 (1:0, 1:1) aet | |
| 16:00 | Enosis Neon Paralimni | - | Olympiada Lympion | 4:1 (3:0) | ||
| 19/10/2022 | 15:00 | Akritas Chlorakas | - | Omonia 29is Maiou | 1:0 (0:0) | |
| 16:00 | Karmiotissa Polemidion | - | Ypsonas FC | 3:2 (1:1) | ||
| 26/10/2022 | 15:00 | PAEEK | - | Anorthosis Famagusta | 1:4 (0:1) |
