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| 1st(1st leg) | Peñarol La Mesilla | - | Deportivo Suchitepéquez | 1:1 | ||
| 2nd (2nd leg) | Deportivo Suchitepéquez | - | Peñarol La Mesilla | 2:1 | ||
| 1st(1st leg): 28/04/2010 22:00 | 2nd (2nd leg): 02/05/2010 18:00 | Winner: Deportivo Suchitepéquez | ||||
| 1st(1st leg) | Universidad SC | - | CSD Municipal | 3:2 | ||
| 2nd (2nd leg) | CSD Municipal | - | Universidad SC | 2:0 | ||
| 1st(1st leg): 30/04/2010 03:00 | 2nd (2nd leg): 02/05/2010 18:00 | Winner: CSD Municipal | ||||
