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| 1st(1st leg) | Deportivo Guastatoya | - | Comunicaciones | 0:0 (0:0) | ||
| 2nd (2nd leg) | Comunicaciones | - | Deportivo Guastatoya | 2:0 (0:0) | ||
| 1st(1st leg): 30/11/2022 17:00 | 2nd (2nd leg): 04/12/2022 00:00 | Winner: Comunicaciones | ||||
| 1st(1st leg) | CSD Municipal | - | Deportivo Malacateco | 2:0 (2:0) | ||
| 2nd (2nd leg) | Deportivo Malacateco | - | CSD Municipal | 1:0 (0:0) | ||
| 1st(1st leg): 30/11/2022 21:00 | 2nd (2nd leg): 03/12/2022 18:00 | Winner: CSD Municipal | ||||
| 1st(1st leg) | Achuapa | - | Antigua GFC | 1:1 (0:0) | ||
| 2nd (2nd leg) | Antigua GFC | - | Achuapa | 2:0 (0:0) | ||
| 1st(1st leg): 01/12/2022 21:00 | 2nd (2nd leg): 05/12/2022 00:00 | Winner: Antigua GFC | ||||
| 1st(1st leg) | Xelaju MC | - | Cobán Imperial | 0:0 (0:0) | ||
| 2nd (2nd leg) | Cobán Imperial | - | Xelaju MC | 1:0 (1:0) | ||
| 1st(1st leg): 02/12/2022 03:00 | 2nd (2nd leg): 04/12/2022 20:30 | Winner: Cobán Imperial | ||||
