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| 1st(1st leg) | Deportivo Guastatoya | - | Antigua GFC | 0:3 (0:2) | ||
| 2nd (2nd leg) | Antigua GFC | - | Deportivo Guastatoya | 2:0 (1:0) | ||
| 1st(1st leg): 30/04/2025 23:00 | 2nd (2nd leg): 04/05/2025 01:00 | Winner: Antigua GFC | ||||
| 1st(1st leg) | Deportivo Malacateco | - | Cobán Imperial | 0:1 (0:1) | ||
| 2nd (2nd leg) | Cobán Imperial | - | Deportivo Malacateco | 2:1 (0:1) | ||
| 1st(1st leg): 01/05/2025 03:00 | 2nd (2nd leg): 03/05/2025 22:00 | Winner: Cobán Imperial | ||||
| 1st(1st leg) | Deportivo Mixco | - | CSD Municipal | 0:0 (0:0) | ||
| 2nd (2nd leg) | CSD Municipal | - | Deportivo Mixco | 4:0 (1:0) | ||
| 1st(1st leg): 01/05/2025 22:00 | 2nd (2nd leg): 04/05/2025 22:00 | Winner: CSD Municipal | ||||
| 1st(1st leg) | Deportivo Marquense | - | Comunicaciones | 2:0 (2:0) | ||
| 2nd (2nd leg) | Comunicaciones | - | Deportivo Marquense | 2:1 (1:1) | ||
| 1st(1st leg): 02/05/2025 00:30 | 2nd (2nd leg): 05/05/2025 01:00 | Winner: Deportivo Marquense | ||||
