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| 1st(1st leg) | Real España | - | Olimpia | 2:2 | ||
| 2nd (2nd leg) | Olimpia | - | Real España | 0:0 | ||
| 1st(1st leg): 25/11/2018 01:00 | 2nd (2nd leg): 02/12/2018 01:00 | Winner: Olimpia | ||||
| 1st(1st leg) | Platense | - | Motagua | 0:1 | ||
| 2nd (2nd leg) | Motagua | - | Platense | 3:1 | ||
| 1st(1st leg): 25/11/2018 22:00 | 2nd (2nd leg): 02/12/2018 22:00 | Winner: Motagua | ||||
