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| 1st(1st leg) | Platense | - | Motagua | 2:4 (1:2) | ||
| 2nd (2nd leg) | Motagua | - | Platense | 0:1 (0:1) | ||
| 1st(1st leg): 17/12/2020 22:00 | 2nd (2nd leg): 20/12/2020 22:00 | Winner: Motagua | ||||
| 1st(1st leg) | Lobos UPNFM | - | Vida | 1:3 (0:2) | ||
| 2nd (2nd leg) | Vida | - | Lobos UPNFM | 5:1 (3:1) | ||
| 1st(1st leg): 19/12/2020 23:00 | 2nd (2nd leg): 23/12/2020 23:15 | Winner: Vida | ||||
