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| 1st(1st leg) | Motagua | - | Real España | 1:1 (0:1) | ||
| 2nd (2nd leg) | Real España | - | Motagua | 2:0 (0:0) | ||
| 1st(1st leg): 05/12/2021 01:00 | 2nd (2nd leg): 12/12/2021 01:00 | Winner: Real España | ||||
| 1st(1st leg) | Olimpia | - | Vida | 2:0 (0:0) | ||
| 2nd (2nd leg) | Vida | - | Olimpia | 2:1 (2:1) | ||
| 1st(1st leg): 05/12/2021 22:00 | 2nd (2nd leg): 12/12/2021 01:30 | Winner: Olimpia | ||||
