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| 1st(1st leg) | Motagua | - | Real España | 3:0 (1:0) | ||
| 2nd (2nd leg) | Real España | - | Motagua | 2:0 (2:0) | ||
| 1st(1st leg): 23/05/2022 00:00 | 2nd (2nd leg): 29/05/2022 22:00 | Winner: Motagua | ||||
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| 1st(1st leg) | Motagua | - | Real España | 3:0 (1:0) | ||
| 2nd (2nd leg) | Real España | - | Motagua | 2:0 (2:0) | ||
| 1st(1st leg): 23/05/2022 00:00 | 2nd (2nd leg): 29/05/2022 22:00 | Winner: Motagua | ||||
