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| 16/12/2021 | 17:35 | Agudat Sport Ashdod | - | Ahva Kafr Manda | 2:0 (1:0) | |
| 17:45 | Hapoel Haifa | - | Hapoel Kfar Saba | 4:2 (0:0, 1:1, 1:1) pso | ||
| 18:00 | Hapoel Petach-Tikva | - | Maccabi Netanya | 0:1 | ||
| 17/12/2021 | 11:00 | Ironi Tiberias | - | Bnei Sachnin FC | 0:3 | |
| 11:00 | Maccabi Sha'arayim | - | Hapoel Rishon LeZion | 2:1 aet | ||
| 11:00 | Maccabi Kabilio Jaffa | - | MS Kafr Qasim | 1:0 | ||
| 11:00 | MS Tzeirey Taibe | - | Ironi Kiryat Shmona | 0:2 | ||
| 12:00 | Maccabi Ahi Nazareth | - | Hapoel Acre FC | 2:1 aet | ||
| 12:00 | FC Ashdod | - | Hapoel Umm al-Fahm | 0:1 | ||
| 18/12/2021 | 13:00 | Maccabi Haifa | - | Hapoel Jerusalem | 1:0 | |
| 15:30 | Hapoel Nof HaGalil | - | Maccabi Petach-Tikva | 0:2 | ||
| 18:00 | Hapoel Hadera | - | FC Tira | 6:1 | ||
| 18:30 | Hapoel Tel Aviv | - | Bnei Yehuda Tel Aviv | 1:3 | ||
| 19/12/2021 | 18:00 | Beitar Tel Aviv Bat Yam | - | Hapoel Be'er Sheva | 0:3 | |
| 18:00 | Beitar Jerusalem | - | Hapoel Afula | 2:1 aet | ||
| 18:00 | Maccabi Tel Aviv | - | Hapoel Marmorek | 4:0 |
