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| 11/12/2022 | 17:00 | Beitar Jerusalem | - | MS Kafr Qasim | 4:0 | |
| 17:00 | Agudat Sport Ashdod | - | Ironi Tiberias | 1:2 | ||
| 17:15 | Hapoel Hadera | - | Hapoel Kfar Saba | 1:3 | ||
| 17:45 | Ironi Kiryat Shmona | - | Maccabi Netanya | 3:4 (1:1, 1:1, 1:1) pso | ||
| 18:00 | Hapoel Umm al-Fahm | - | Maccabi Tel Aviv | 2:3 | ||
| 12/12/2022 | 11:00 | Hapoel Qalansawe | - | Bnei Sachnin FC | 0:3 | |
| 11:00 | Ihud Bnei Shfaram | - | Hapoel Haifa | 2:4 pso | ||
| 11:00 | FC Tira | - | Hapoel Petach-Tikva | 2:3 aet | ||
| 17:30 | Hapoel Rishon LeZion | - | Maccabi Bnei Raina | 0:3 | ||
| 17:30 | Hapoel Jerusalem | - | Maccabi Petach-Tikva | 0:1 | ||
| 17:30 | Hapoel Acre FC | - | Sektzia Nes Tziona | 2:3 | ||
| 17:30 | Maccabi Ahi Nazareth | - | MK Tzofi Haifa | 5:1 | ||
| 17:30 | FC Ashdod | - | Hapoel Be'er Sheva | 2:1 | ||
| 17:30 | Hapoel Nir Ramat HaSharon | - | Holon Yermiyahu | 2:0 | ||
| 17:45 | Hapoel Afula | - | Hapoel Tel Aviv | 1:0 | ||
| 18:00 | Hapoel Nof HaGalil | - | Maccabi Haifa | 0:1 |
