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| 1st(1st leg) | Managua FC | - | Real Estelí FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Real Estelí FC | - | Managua FC | 2:0 (0:0) | ||
| 1st(1st leg): 07/12/2022 22:00 | 2nd (2nd leg): 12/12/2022 01:00 | Winner: Real Estelí FC | ||||
| 1st(1st leg) | CD Walter Ferretti | - | Diriangén FC | 1:1 (0:0) | ||
| 2nd (2nd leg) | Diriangén FC | - | CD Walter Ferretti | 3:5 (0:0, 0:0, 1:1) pso | ||
| 1st(1st leg): 09/12/2022 00:00 | 2nd (2nd leg): 11/12/2022 23:00 | Winner: CD Walter Ferretti | ||||
