1st(1st leg) Alianza - Atlético Chiriquí 1:0 (1:0)
2nd (2nd leg) Atlético Chiriquí - Alianza -:-
1st(1st leg): 15/05/2022 02:00 2nd (2nd leg): 22/05/2022 02:00
1st(1st leg) Tauro FC - Sporting San Miguelito 1:2 (0:1)
2nd (2nd leg) Sporting San Miguelito - Tauro FC -:-
1st(1st leg): 16/05/2022 00:30 2nd (2nd leg): 23/05/2022 00:00