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| 1st(1st leg) | Dolce Bretaña | - | FC Cajamarca | 1:1 (0:1) | ||
| 2nd (2nd leg) | FC Cajamarca | - | Dolce Bretaña | 2:0 | ||
| 1st(1st leg): 16/11/2024 20:00 | 2nd (2nd leg): 24/11/2024 20:30 | Winner: FC Cajamarca | ||||
| 1st(1st leg) | Juventud Unión Soratira | - | Nacional FBC | 1:0 | ||
| 2nd (2nd leg) | Nacional FBC | - | Juventud Unión Soratira | 4:3 pso | ||
| 1st(1st leg): 16/11/2024 20:00 | 2nd (2nd leg): 24/11/2024 20:00 | Winner: Nacional FBC | ||||
| 1st(1st leg) | FCR San Antonio | - | Juventud Alfa | 3:0 | ||
| 2nd (2nd leg) | Juventud Alfa | - | FCR San Antonio | 1:0 | ||
| 1st(1st leg): 17/11/2024 18:00 | 2nd (2nd leg): 24/11/2024 20:00 | Winner: FCR San Antonio | ||||
| 1st(1st leg) | Lute Zaña | - | Ucrania | 2:0 | ||
| 2nd (2nd leg) | Ucrania | - | Lute Zaña | 4:1 | ||
| 1st(1st leg): 17/11/2024 18:00 | 2nd (2nd leg): 24/11/2024 18:00 | Winner: Ucrania | ||||
| 1st(1st leg) | Municipal de Vice | - | Ecosem Pasco | 1:0 | ||
| 2nd (2nd leg) | Ecosem Pasco | - | Municipal de Vice | 3:0 | ||
| 1st(1st leg): 17/11/2024 18:00 | 2nd (2nd leg): 24/11/2024 18:00 | Winner: Ecosem Pasco | ||||
| 1st(1st leg) | Centro Social | - | Sport Bolognesi | 4:3 | ||
| 2nd (2nd leg) | Sport Bolognesi | - | Centro Social | 4:5 pso | ||
| 1st(1st leg): 17/11/2024 18:00 | 2nd (2nd leg): 24/11/2024 20:00 | Winner: Centro Social | ||||
| 1st(1st leg) | Diablos Rojos Juliaca | - | Viargoca FC | 3:0 | ||
| 2nd (2nd leg) | Viargoca FC | - | Diablos Rojos Juliaca | 4:3 pso | ||
| 1st(1st leg): 17/11/2024 20:00 | 2nd (2nd leg): 24/11/2024 20:00 | Winner: Viargoca FC | ||||
| 1st(1st leg) | Juventud Santo Domingo | - | Defensor JSM | 1:0 | ||
| 2nd (2nd leg) | Defensor JSM | - | Juventud Santo Domingo | 2:3 pso | ||
| 1st(1st leg): 17/11/2024 20:00 | 2nd (2nd leg): 24/11/2024 18:00 | Winner: Juventud Santo Domingo | ||||
| 1st(1st leg) | Municipal de Pangoa | - | Juventud Cautivo | 0:2 | ||
| 2nd (2nd leg) | Juventud Cautivo | - | Municipal de Pangoa | 3:1 | ||
| 1st(1st leg): 17/11/2024 20:00 | 2nd (2nd leg): 24/11/2024 20:00 | Winner: Juventud Cautivo | ||||
| 1st(1st leg) | Tiro N.° 28 | - | Bentín Tacna Heroica | 1:1 | ||
| 2nd (2nd leg) | Bentín Tacna Heroica | - | Tiro N.° 28 | 1:0 | ||
| 1st(1st leg): 17/11/2024 20:00 | 2nd (2nd leg): 24/11/2024 20:00 | Winner: Bentín Tacna Heroica | ||||
| 1st(1st leg) | Cultural Volante | - | Construcción Civil | 1:0 | ||
| 2nd (2nd leg) | Construcción Civil | - | Cultural Volante | 1:1 | ||
| 1st(1st leg): 17/11/2024 20:00 | 2nd (2nd leg): 24/11/2024 20:00 | Winner: Cultural Volante | ||||
| 1st(1st leg) | Estudiantil CNI | - | Juventus Huamachuco | 1:0 | ||
| 2nd (2nd leg) | Juventus Huamachuco | - | Estudiantil CNI | 2:1 | ||
| 1st(1st leg): 17/11/2024 20:00 | 2nd (2nd leg): 25/11/2024 20:30 | Winner: Estudiantil CNI | ||||
| 1st(1st leg) | Amazon Callao | - | Unión Santo Domingo | 2:1 (1:0) | ||
| 2nd (2nd leg) | Unión Santo Domingo | - | Amazon Callao | 3:2 pso | ||
| 1st(1st leg): 17/11/2024 20:30 | 2nd (2nd leg): 24/11/2024 20:30 | Winner: Unión Santo Domingo | ||||
| 1st(1st leg) | Deportivo El Inca | - | Rauker FC | 3:2 | ||
| 2nd (2nd leg) | Rauker FC | - | Deportivo El Inca | 0:0 | ||
| 1st(1st leg): 17/11/2024 20:30 | 2nd (2nd leg): 24/11/2024 20:00 | Winner: Deportivo El Inca | ||||
| 1st(1st leg) | Tacna Libre | - | Pacífico FC | 0:3 | ||
| 2nd (2nd leg) | Pacífico FC | - | Tacna Libre | 6:0 | ||
| 1st(1st leg): 17/11/2024 20:30 | 2nd (2nd leg): 24/11/2024 20:30 | Winner: Pacífico FC | ||||
| 1st(1st leg) | Nacional La Joya | - | Nuevo San Cristóbal | 1:0 | ||
| 2nd (2nd leg) | Nuevo San Cristóbal | - | Nacional La Joya | 3:0 | ||
| 1st(1st leg): 17/11/2024 21:00 | 2nd (2nd leg): 24/11/2024 18:00 | Winner: Nuevo San Cristóbal | ||||
