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| 1st(1st leg) | Pasaquina FC | - | Santa Tecla FC | 2:2 | ||
| 2nd (2nd leg) | Santa Tecla FC | - | Pasaquina FC | 4:0 | ||
| 1st(1st leg): 11/05/2016 21:30 | 2nd (2nd leg): 14/05/2016 23:00 | Winner: Santa Tecla FC | ||||
| 1st(1st leg) | Dragón | - | Luis Ángel Firpo | 3:0 | ||
| 2nd (2nd leg) | Luis Ángel Firpo | - | Dragón | 2:0 | ||
| 1st(1st leg): 12/05/2016 00:30 | 2nd (2nd leg): 15/05/2016 01:30 | Winner: Dragón | ||||
| 1st(1st leg) | AD Chalatenango | - | CD Águila | 0:4 | ||
| 2nd (2nd leg) | CD Águila | - | AD Chalatenango | 0:1 | ||
| 1st(1st leg): 12/05/2016 02:00 | 2nd (2nd leg): 15/05/2016 01:30 | Winner: CD Águila | ||||
| 1st(1st leg) | Isidro Metapán | - | Alianza | 0:0 | ||
| 2nd (2nd leg) | Alianza | - | Isidro Metapán | 1:0 | ||
| 1st(1st leg): 12/05/2016 02:30 | 2nd (2nd leg): 15/05/2016 22:15 | Winner: Alianza | ||||
