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| 1st(1st leg) | Once Municipal | - | Alianza | 1:1 (1:0) | ||
| 2nd (2nd leg) | Alianza | - | Once Municipal | 2:0 (1:0) | ||
| 1st(1st leg): 08/12/2021 21:30 | 2nd (2nd leg): 12/12/2021 21:00 | Winner: Alianza | ||||
| 1st(1st leg) | AD Chalatenango | - | Platense Zacatecoluca | 1:1 (1:0) | ||
| 2nd (2nd leg) | Platense Zacatecoluca | - | AD Chalatenango | 1:0 (0:0) | ||
| 1st(1st leg): 10/12/2021 01:00 | 2nd (2nd leg): 12/12/2021 21:00 | Winner: Platense Zacatecoluca | ||||
