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| 1st(1st leg) | CD Cacahuatique | - | Alianza | 1:2 (0:1) | ||
| 2nd (2nd leg) | Alianza | - | CD Cacahuatique | 4:0 (2:0) | ||
| 1st(1st leg): 07/05/2025 22:00 | 2nd (2nd leg): 10/05/2025 22:15 | Winner: Alianza | ||||
| 1st(1st leg) | Municipal Limeño | - | Isidro Metapán | 2:1 (1:1) | ||
| 2nd (2nd leg) | Isidro Metapán | - | Municipal Limeño | 1:2 (0:0) | ||
| 1st(1st leg): 08/05/2025 02:30 | 2nd (2nd leg): 11/05/2025 03:15 | Winner: Municipal Limeño | ||||
| 1st(1st leg) | FAS | - | CD Águila | 1:2 (1:0) | ||
| 2nd (2nd leg) | CD Águila | - | FAS | 2:3 (0:0, 0:1) pso | ||
| 1st(1st leg): 08/05/2025 03:00 | 2nd (2nd leg): 11/05/2025 22:15 | Winner: FAS | ||||
| 1st(1st leg) | Fuerte San Francisco | - | Luis Ángel Firpo | 0:0 (0:0) | ||
| 2nd (2nd leg) | Luis Ángel Firpo | - | Fuerte San Francisco | 3:4 (0:1, 1:1) pso | ||
| 1st(1st leg): 08/05/2025 22:30 | 2nd (2nd leg): 11/05/2025 02:00 | Winner: Fuerte San Francisco | ||||
