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| 01/09/2010 | 15:30 | FK Srem Jakovo | - | ČSK Pivara | 1:0 | |
| 15:30 | Mladost Apatin | - | Radnički Sombor | 3:2 | ||
| 15:30 | Sloga Petrovac | - | FK Zemun | 5:3 pso | ||
| 15:30 | FK Sinđelić Niš | - | Dinamo Vranje | 2:0 | ||
| 15:30 | FK Donji Srem Pećinci | - | FK Banat Zrenjanin | 3:2 | ||
| 15:30 | FK Mokra Gora | - | Mladost Lučani | 5:4 pso | ||
| 15:30 | Sloga Kraljevo | - | Radnički Niš | 2:1 |
