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| 11/11/2022 | 19:30 | Penydarren Boys & Girls | - | Trethomas Bluebirds | 1:0 | |
| 19:45 | The New Saints | - | Caernarfon Town | 2:1 (1:0) | ||
| 12/11/2022 | 12:45 | Connah's Quay Nomads | - | Colwyn Bay FC | 4:0 | |
| 14:00 | Cefn Druids | - | Llanelli Town | 3:4 | ||
| 14:00 | Ruthin Town | - | Pontypridd United | 3:4 | ||
| 14:00 | Pontardawe Town | - | Pill AFC | 3:1 | ||
| 14:00 | Guilsfield FC | - | Goytre United | 6:3 | ||
| 14:00 | Conwy Borough FC | - | Penybont FC | 0:3 | ||
| 14:00 | Cwmbran Celtic | - | Carmarthen Town | 4:3 | ||
| 14:00 | Buckley Town | - | Prestatyn Town | 0:3 | ||
| 14:00 | Aberystwyth Town | - | Newtown AFC | 1:3 | ||
| 14:00 | Airbus UK | - | Trefelin BGC | 2:1 | ||
| 14:00 | Bala Town | - | Flint Town United | 2:0 | ||
| 14:00 | Hakin United | - | Holywell Town | 1:5 | ||
| 14:00 | Mold Alexandra | - | Briton Ferry Llansawel AFC | 0:4 | ||
| 14:30 | Barry Town United | - | Gresford Athletic | 0:2 |
