 |
 |
| Quarter-finals | ||||||
|---|---|---|---|---|---|---|
| 27/11/2021 | 15:00 | Deportivo Toluca | - | Club León | 0:1 (0:1) | |
| 16:00 | Santos Laguna | - | CF Pachuca | 1:5 (0:1) | ||
| 16:00 | Deportivo Guadalajara | - | Cruz Azul | 2:1 (0:1) | ||
| 16:00 | Pumas UNAM | - | UANL Tigres | 2:0 (1:0) | ||
| Semi-finals | ||||||
| 04/12/2021 | 16:00 | CF Pachuca | - | Club León | 2:0 (2:0) | |
| 16:00 | Deportivo Guadalajara | - | Pumas UNAM | 4:1 (2:0) | ||
| Final | ||||||
| 09/12/2021 | 00:00 | CF Pachuca | - | Deportivo Guadalajara | 2:1 (0:0) | |
| 11/12/2021 | 16:00 | Deportivo Guadalajara | - | CF Pachuca | 1:0 (0:0) | |
