Qualifier
08/09/2021 15:00 FK Sloga Požega - FK Kabel 4:1
15:00 FK Mokra Gora - Budućnost Dobanovci 7:8 pso
15:00 SFS Borac Paraćin - FK Žarkovo 0:2
15:00 Radnički Beograd - FK Sloga Kraljevo 3:1
15:00 Jedinstvo Rumenka - FK Loznica 0:3
15:00 FK Trayal - FK Grafičar 1:0
15:00 FK Železničar Pančevo - Radnički Pirot 3:0
15:00 Radnički Sremska Mitrovica - FK Kolubara 0:1
15:00 FK Zemun - Dinamo Vranje 0:1
15:00 Dubočica Leskovac - IMT Beograd 1:0
17:00 Borac Čačak - FK Jagodina 2:4 pso
1. Round
13/10/2021 13:00 Radnik Surdulica - FK Radnički 1923 2:0 (2:0)
15:30 Partizan - FK Trayal 3:0 (1:0)
14/10/2021 16:00 FK Metalac - FK Žarkovo 3:2 (2:1)
27/10/2021 13:00 FK Novi Pazar - Budućnost Dobanovci 1:0 (0:0)
13:00 FK Sloga Požega - FK Rad Beograd 0:1 (0:1)
13:30 FK Loznica - FK Čukarički 1:0 (1:0)
13:30 FK Železničar Pančevo - FK Napredak 0:1 (0:1)
13:30 Radnički Niš - Dinamo Vranje 1:0 (0:0)
13:30 OFK Bačka - Proleter Novi Sad 3:2 (0:1) pso
13:30 FK Zlatibor - TSC Bačka Topola 0:4 (0:2)
13:30 Radnički Beograd - FK Voždovac 2:1 (2:0)
14:00 FK Javor - FK Mačva Šabac 2:1 (2:1)
15:00 Vojvodina - FK Jagodina 5:1 (2:1)
15:00 Spartak Subotica - Dubočica Leskovac 4:5 (1:1) pso
16:00 Mladost Lučani - FK Kolubara 2:3 (0:1)
18/11/2021 12:00 FK Inđija - Crvena Zvezda 0:1 (0:1)
Round of 16
30/11/2021 11:55 Radnički Beograd - FK Metalac 2:3 (0:1, 1:1) pso
01/12/2021 12:00 FK Rad Beograd - FK Napredak 1:0 (1:0)
12:00 Radnik Surdulica - FK Loznica 1:2 (0:0)
12:00 TSC Bačka Topola - FK Kolubara 2:1 (1:0)
15:15 Dubočica Leskovac - Partizan 0:1 (0:1)
02/12/2021 12:00 FK Novi Pazar - OFK Bačka 2:0 (1:0)
14:00 FK Javor - Vojvodina 1:4 (0:0, 1:1) pso
16/02/2022 16:00 Crvena Zvezda - Radnički Niš 3:2 (0:0, 0:0) pso
Quarter-finals
06/04/2022 15:00 FK Novi Pazar - FK Metalac 1:0 (1:0)
16:00 Partizan - FK Loznica 2:0 (2:0)
17:30 FK Rad Beograd - Vojvodina 0:4 (0:4)
17:30 Crvena Zvezda - TSC Bačka Topola 4:0 (1:0)
Semi-finals
11/05/2022 15:30 Partizan - Vojvodina 2:1 (2:0)
17:30 Crvena Zvezda - FK Novi Pazar 8:0 (5:0)
Final
26/05/2022 17:00 Partizan - Crvena Zvezda 1:2 (0:1)