1. Round
17/10/2021 Asteras Vlachioti Asteras Vlachioti - Irodotos Irodotos resch.
17/10/2021 Diagoras FC Diagoras FC - AEK Athen II AEK Athen II resch.
17/10/2021 Ergotelis Ergotelis - AO Egaleo AO Egaleo resch.
17/10/2021 Kallithea GS Kallithea GS - AO Episkopi AO Episkopi resch.
17/10/2021 AE Kifisias AE Kifisias - AS Rhodos AS Rhodos resch.
17/10/2021 Levadiakos Levadiakos - AE Karaiskakis AE Karaiskakis resch.
17/10/2021 OFI Ierapetra OFI Ierapetra - Panathinaikos II Panathinaikos II resch.
17/10/2021 PAE Chania PAE Chania - Kalamata Kalamata resch.