2. Round
14/09/2021 14:00 FC Olimpia FC Olimpia - FC Sîngerei FC Sîngerei 1:3
14/09/2021 14:00 CS Cruiz-Plus CS Cruiz-Plus - FCM Ungheni FCM Ungheni 1:4
14/09/2021 14:00 ARF Ocniţa ARF Ocniţa - Speranța Drochia Speranța Drochia 0:4
14/09/2021 14:00 FC Real-Succes FC Real-Succes - Olimp Comrat Olimp Comrat 1:8
14/09/2021 14:00 FC Saxan FC Saxan - Sporting Trestieni Sporting Trestieni 3:2 aet
14/09/2021 14:00 FC Maiak Chirsova FC Maiak Chirsova - FC Cahul 2005 FC Cahul 2005 2:4
14/09/2021 14:00 Sparta Selemet Sparta Selemet - Dacia Buiucani Dacia Buiucani 2:0 aet
14/09/2021 14:00 CF Soroca CF Soroca - Victoria Bardar Victoria Bardar 0:1