Quarter-finals
01/12/2021 12:00 Sileks Kratovo Sileks Kratovo - FK Bregalnica Štip FK Bregalnica Štip 5:4 (0:0, 1:1) pso
01/12/2021 12:00 KF Shkëndija 79 KF Shkëndija 79 - FC Struga FC Struga 3:4 (0:0, 0:0) pso
01/12/2021 12:00 Makedonija GP Makedonija GP - KF Shkupi KF Shkupi 4:1 (0:0, 0:0) pso
15/12/2021 12:00 FK Pelister FK Pelister - Vardar Skopje Vardar Skopje