Round of 16
26/10/2021 17:30 Metalist 1925 Kharkov Metalist 1925 Kharkov - FC Oleksandriya FC Oleksandriya -:-
27/10/2021 12:00 NK Veres NK Veres - Vorskla Poltava Vorskla Poltava -:-
27/10/2021 15:00 FK Mariupol FK Mariupol - Dinamo Kiev Dinamo Kiev -:-
27/10/2021 17:30 Chernomorets Odessa Chernomorets Odessa - Shakhtar Donetsk Shakhtar Donetsk -:-
28/10/2021 12:00 Alians Lypova Dolyna Alians Lypova Dolyna - FK Lviv FK Lviv -:-
28/10/2021 15:00 FC LNZ Cherkasy FC LNZ Cherkasy - SK Dnipro-1 SK Dnipro-1 -:-
28/10/2021 17:00 Rukh Lviv Rukh Lviv - Zorya Lugansk Zorya Lugansk -:-
28/10/2021 17:30 Metalist Kharkov Metalist Kharkov - Kolos Kovalivka Kolos Kovalivka -:-