| 6. Round | 11/09/2021 | Montpellier HSC B | - | Canet Roussillon | 0:0 |  |
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| 7. Round | 17/09/2021 | Angoulême CFC | - | Montpellier HSC B | 3:2 | ||||
| 12. Round | 20/11/2021 | Montpellier HSC B | - | Bourges Foot 18 | 2:3 | ||||
| 13. Round | 04/12/2021 | Le Puy Foot 43 | - | Montpellier HSC B | 2:0 | ||||
| 14. Round | 11/12/2021 | Montpellier HSC B | - | Angers SCO B | 0:4 | ||||
| 15. Round | 15/01/2022 | Vendée Les Herbiers | - | Montpellier HSC B | 2:1 | |
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| 16. Round | 22/01/2022 | FC Chamalières | - | Montpellier HSC B | 1:2 | ||||
| 17. Round | 05/02/2022 | Montpellier HSC B | - | Andrézieux-Bouthéon FC | 0:2 | |
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| 18. Round | 12/02/2022 | US Colomiers | - | Montpellier HSC B | 1:1 | ||||
| 19. Round | 18/02/2022 | Montpellier HSC B | - | FC Nantes B | 0:0 | ||||
| 20. Round | 05/03/2022 | Canet Roussillon | - | Montpellier HSC B | 0:1 | |
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| 21. Round | 12/03/2022 | Montpellier HSC B | - | Angoulême CFC | 0:0 | ||||
| 23. Round | 26/03/2022 | Montpellier HSC B | - | Moulins Yzeure Foot | 4:2 |
France
Morocco