| 6. Round | 11/09/2021 | SC Toulon | - | AS Monaco B | 3:0 | ||||
| 16. Round | 22/01/2022 | RC Grasse | - | AS Monaco B | 0:0 | ||||
| 18. Round | 12/02/2022 | Hyères FC | - | AS Monaco B | 3:1 | ||||
| 19. Round | 19/02/2022 | AS Monaco B | - | Lyon-La Duchère | 2:2 | ||||
| 20. Round | 05/03/2022 | AS Monaco B | - | SC Toulon | 0:1 | ||||
| 21. Round | 12/03/2022 | FC Martigues | - | AS Monaco B | 1:2 | ||||
| 22. Round | 19/03/2022 | AS Monaco B | - | GFA Rumilly Vallières | 2:2 |  |
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| 23. Round | 26/03/2022 | AS Saint-Priest | - | AS Monaco B | 2:1 | ||||
| 26. Round | 23/04/2022 | AS Monaco B | - | Aubagne FC | 1:1 | ||||
| 27. Round | 30/04/2022 | Jura Sud | - | AS Monaco B | 5:0 | ||||
| 28. Round | 14/05/2022 | AS Monaco B | - | Olympique Marseille B | 2:4 | ||||
| 30. Round | 28/05/2022 | AS Monaco B | - | Olympique Lyonnais B | 4:1 |
Mali