1. Round | 06/01/2022 | Alebrijes de Oaxaca | - | Cancún FC | 2:0 | ||||
2. Round | 12/01/2022 | Cancún FC | - | Club Celaya | 2:0 | ||||
3. Round | 18/01/2022 | Cancún FC | - | Dorados de Sinaloa | 1:2 | ||||
5. Round | 31/01/2022 | Cancún FC | - | Atlante | 1:2 | ||||
6. Round | 03/02/2022 | TM Fútbol Club | - | Cancún FC | 1:2 | ||||
7. Round | 08/02/2022 | Cancún FC | - | Tepatitlán | 2:1 | ||||
8. Round | 18/02/2022 | Atlético Morelia | - | Cancún FC | 4:1 | ||||
9. Round | 24/02/2022 | Cancún FC | - | CF Monterrey II | 0:0 |