| 2. Round | 31/07/2021 | FShM Moskva [Youth] | - | FK Saturn [Youth] | 2:5 |  |
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| 3. Round | 07/08/2021 | FK Saturn [Youth] | - | Zenit St. Petersburg [Youth] | 1:2 | ||||
| 4. Round | 14/08/2021 | FK Saturn [Youth] | - | FK Krasnodar [Youth] | 2:2 | |
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| 5. Round | 21/08/2021 | FK Saturn [Youth] | - | Kuban Krasnodar [Youth] | 1:1 | ||||
| 6. Round | 25/08/2021 | FK Saturn [Youth] | - | Spartak Moskva [Youth] | 0:6 | ||||
| 7. Round | 11/09/2021 | Dinamo Moskva [Youth] | - | FK Saturn [Youth] | 3:4 | |
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| 8. Round | 18/09/2021 | FK Saturn [Youth] | - | CSKA Moskva [Youth] | 3:5 |  |
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| 9. Round | 25/09/2021 | Lokomotiv Moskva [Youth] | - | FK Saturn [Youth] | 5:0 | ||||
| 10. Round | 02/10/2021 | FK Saturn [Youth] | - | FK Strogino Moskva [Youth] | 1:0 | |
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| 11. Round | 16/10/2021 | Chertanovo Football Academy [Youth] | - | FK Saturn [Youth] | 5:2 | |
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| 15. Round | 20/11/2021 | FK Saturn [Youth] | - | FShM Moskva [Youth] | 1:2 | ||||
| 16. Round | 28/11/2021 | Zenit St. Petersburg [Youth] | - | FK Saturn [Youth] | 8:1 | |
Tajikistan