| 1. Round | 08/01/2022 | Gallos Blancos [U16] | - | CF América [U16] | 0:3 | ||||
| 2. Round | 15/01/2022 | CF América [U16] | - | Pumas UNAM [U16] | 1:0 |  |
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| 4. Round | 29/01/2022 | CF Pachuca [U16] | - | CF América [U16] | 0:3 | ||||
| 3. Round | 09/02/2022 | CF América [U16] | - | Puebla FC [U16] | 1:0 |  |
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| 6. Round | 12/02/2022 | FC Juárez [U16] | - | CF América [U16] | 1:0 | ||||
| 7. Round | 19/02/2022 | CF América [U16] | - | Club Necaxa [U16] | 3:2 | ||||
| 11. Round | 19/03/2022 | Pumas UNAM [U16] | - | CF América [U16] | 1:0 | ||||
| 15. Round | 16/04/2022 | Deportivo Toluca [U16] | - | CF América [U16] | 1:2 | |
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| 16. Round | 23/04/2022 | CF América [U16] | - | CF Pachuca [U16] | 2:0 | ||||
| 14. Round | 27/04/2022 | CF América [U16] | - | Cruz Azul [U16] | 1:0 | |
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| 17. Round | 30/04/2022 | Puebla FC [U16] | - | CF América [U16] | 1:2 | ||||
| 18. Round | 07/05/2022 | CF América [U16] | - | FC Juárez [U16] | 3:3 | |
Mexico