| 1. Round | 19/09/2020 | Saltillo FC | - | Mineros de Fresnillo FC | 2:2 | ||||
| 2. Round | 25/09/2020 | Mazorqueros | - | Saltillo FC | 1:1 |  |
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| 3. Round | 02/10/2020 | Saltillo FC | - | Atlético San Luis II | 1:3 | ||||
| 6. Round | 25/10/2020 | Tuzos de la UAZ | - | Saltillo FC | 0:0 |  |
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| 5. Round | 31/10/2020 | Saltillo FC | - | Gavilanes de Matamoros | 0:0 | ||||
| 4. Round | 29/11/2020 | Reboceros de La Piedad | - | Saltillo FC | 7:0 | ||||
| 11. Round | 10/12/2020 | Tecos Fútbol Club | - | Saltillo FC | 0:0 | ||||
| 19. Round | 13/03/2021 | Saltillo FC | - | Cimarrones de Sonora II | 1:0 | ||||
| 20. Round | 20/03/2021 | Saltillo FC | - | Colima FC | 0:1 | |
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| 21. Round | 03/04/2021 | Leones Negros II | - | Saltillo FC | 3:0 |
Mexico